Neonatal Outcomes after Use of Buprenorphine during Pregnancy

The opioid crisis in the United States has had profound effects on pregnant persons and their children. Over the past decade, the rate of opioid-related diagnoses during pregnancy has increased across nearly all states and demographic groups,(1) and overdose is now a leading cause of pregnancy-related deaths.(2) In pregnancy, the use of medications such as methadone and buprenorphine for opioid use disorder reduces the risks of overdose and preterm birth and is the recommended evidence-based treatment approach for pregnant persons with the disorder.(3,4) For more than 30 years, methadone was the medication that was predominantly used to treat opioid use . . .