Advanced Squamous Cell Carcinoma of the Head and Neck: The Current Role of Cetuximab

被引：4
|
作者：
Granados-Garcia, Martin [1 ]
Luis Aguilar-Ponce, Jose [2 ]
Maldonado-Magos, Federico [3 ]
De la Garza-Salazar, Jaime G. [2 ]
机构：
[1] Inst Nacl Cancerol, Head & Neck Canc Dept, San Fernando 22,Col Secc 15, Mexico City 14400, DF, Mexico
[2] Inst Nacl Cancerol, Subdirect Internal Med, Mexico City, DF, Mexico
[3] Inst Nacl Cancerol, Subdirect Radiat Therapy, Mexico City, DF, Mexico
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY | 2016年 / 78卷 / 06期
关键词：
Head and neck cancer; Advanced squamous cell carcinoma of the head and neck; Chemoradiotherapy; Bioradiotherapy; Cetuximab; PLATINUM-BASED CHEMOTHERAPY; LOCALLY ADVANCED HEAD; QUALITY-OF-LIFE; RADIOTHERAPY PLUS CETUXIMAB; COOPERATIVE-ONCOLOGY-GROUP; PREVIOUSLY-IRRADIATED HEAD; PHASE-II MULTICENTER; INDUCED SKIN RASH; CANCER PATIENTS; 1ST-LINE TREATMENT;
D O I：
10.1159/000455891
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
We review clinical trials of squamous cell carcinoma of the head and neck (SCCHN) to address the current and potential uses of cetuximab (CTX). PubMed was reviewed to identify papers published between 2010 and 2016. The search terms used were "cetuximab" and "head and neck cancer." A total of 634 articles were identified. Phase II or III studies with CTX in patients with advanced SCCHN without treatment or with recurrent/metastatic tumors were selected. Forty-six registries were obtained. Information was critically reviewed and relevant information presented. As definitive treatment of advanced squamous cells carcinomas and as palliative treatment of recurrent/metastatic disease, CTX alone or associated with chemotherapy and/or radiotherapy is an alternative to chemoradiotherapy because of its distinct and favorable toxicity profile. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：320 / 333
页数：14
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