Incidence and Predictors of Ischemic Stroke Events during Hospitalization in Patients with Transient Ischemic Attack

被引：14

作者：

Fujinami, Jun ^{[1
]}

Uehara, Toshiyuki ^{[1
]}

Kimura, Kazumi ^{[3
]}

Okada, Yasushi ^{[4
]}

Hasegawa, Yasuhiro ^{[5
]}

Tanahashi, Norio ^{[6
]}

Suzuki, Akifumi ^{[7
]}

Takagi, Shigeharu ^{[8
]}

Nakagawara, Jyoji ^{[9
]}

Arii, Kazumasa ^{[10
]}

Nagahiro, Shinji ^{[12
]}

Ogasawara, Kuniaki ^{[13
]}

Nagao, Takehiko ^{[11
]}

Uchiyama, Shinichiro ^{[11
]}

Matsumoto, Masayasu ^{[14
]}

Iihara, Koji ^{[2
]}

Minematsu, Kazuo ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Cerebrovasc Med, Suita, Osaka 5658565, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Dept Neurosurg, Suita, Osaka 5658565, Japan

[3] Kawasaki Med Sch, Dept Stroke Med, Kurashiki, Okayama, Japan

[4] Natl Hosp Org Kyushu Med Ctr, Clin Res Inst, Dept Cerebrovasc Med & Neurol, Fukuoka, Japan

[5] Nagoya Daini Red Cross Hosp, Dept Neurol, Nagoya, Aichi, Japan

[6] Saitama Med Univ, Saitama Int Med Ctr, Dept Neurol & Cerebrovasc Med, Hidaka, Japan

[7] Res Inst Brain & Blood Vessels, Dept Stroke Sci, Akita, Japan

[8] Tokai Univ, Dept Neurol, Isehara, Kanagawa, Japan

[9] Nakamura Mem Hosp, Dept Neurosurg, Sapporo, Hokkaido, Japan

[10] Ebara Hosp, Dept Neurol, Tokyo, Japan

[11] Tokyo Womens Med Univ, Dept Neurol, Tokyo, Japan

[12] Univ Tokushima, Dept Neurosurg, Tokushima 770, Japan

[13] Iwate Med Univ, Dept Neurosurg, Morioka, Iwate 020, Japan

[14] Hiroshima Univ, Dept Clin Neurosci & Therapeut, Hiroshima, Japan

来源：

CEREBROVASCULAR DISEASES | 2014年 / 37卷 / 05期

关键词：

Acute ischemic stroke; Diffusion-weighted image; Incidence; Predictors of outcome; Transient ischemic attack; ABCD(2) SCORE; MINOR STROKE; EARLY RISK; PATTERNS;

D O I：

10.1159/000360757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA. Methods: We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization. Results: A total of 464 patients with TIA (292 men, 69 +/- 13 years) were registered. Of those, 400 (86.2%) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95% CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95% CI: 1.155.25), and hemiparesis (OR: 2.30; 95% CI: 1.02-5.88) were independently associated with ischemic events during hospitalization. Conclusions: In this study, 1.7% of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis. (C) 2014 S. Karger AG, Basel

引用

页码：330 / 335

页数：6

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