Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery

被引：11

作者：

Du, Fengyi ^{[1
,2
]}

Wu, Yunchao ^{[2
]}

Du, Fengting ^{[3
]}

Zhang, Lirong ^{[3
]}

Feng, Weiwei ^{[4
]}

Zhao, Lulu ^{[2
]}

Cai, Rong ^{[3
]}

Xu, Lixia ^{[2
]}

Bian, Gaorui ^{[5
]}

Li, Jiangang ^{[5
]}

Zou, Shengqiang ^{[1
]}

Gong, Aihua ^{[2
]}

Zhang, Miaomiao ^{[2
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp Zhenjiang 3, Dept Hepatosis, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Jiangsu Univ, Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China

[3] Huangnihe Town Hosp, Dept Physiotherapy, Huangnihe 133704, Peoples R China

[4] Jiangsu Univ, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[5] Tianyi Hlth Sci Inst Zhenjiang Co Ltd, Zhenjiang 212013, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2019年 / 14卷

基金：

中国博士后科学基金;

关键词：

catechol; mucoadhesive; microcapsules; CT imaging; gastroretentive drug delivery; ORAL DELIVERY; NANOPARTICLES; POLYMER; HYDROGELS; PROMOTES; RELEASE; SYSTEMS; MODEL; RATS;

D O I：

10.2147/IJN.S204237

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Background: The gastroretentive drug delivery system is an effective administration route, which can improve the bioavailability of the drug and the therapeutic effect by prolonging the release time of the drug and controlling the release rate in the stomach. Methods: Inspired by the excellent adhesion properties of mussel protein, we prepared novel catechol-grafted chitosan alginate/barium sulfate microcapsules (Cat-CA/BS MCs) with mucoadhesive properties and computed tomography (CT) imaging function for gastric drug delivery. First, barium sulfate nanoclusters used as CT contrast agent were synthesized in situ in the Cat-CA/BS MCs through a one-step electronic spinning method. Next, catechol-grafted chitosan as the mucoadhesive moiety was coated on the surface of Cat-CA/BS MCs by polyelectrolyte molecule self-assembly. Results: The prepared Cat-CA/BS MCs could effectively retained in the stomach for 48 hours and successively released ranitidine hydrochloride, which could be used for the treatment of gastric ulcer. Cat-CA/BS MCs exhibited superior CT contrast imaging properties for real-time tracking in vivo after oral administration. Conclusion: These findings demonstrate that Cat-CA/BS MCs serving as multifunctional oral drug carriers possess huge potential in gastroretentive drug delivery and non-invasive visualization.

引用

页码：6001 / 6018

页数：18