Selective formation of C-N and C=N bonds via C(sp3)-H activation of isochroman in the presence of DTBP

被引：17
|
作者：
Feng, J. [1 ]
Lv, M. F. [1 ]
Lu, G. P. [1 ]
Cai, C. [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Jiangsu, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 01期
关键词：
H BONDS; SIMPLE ALKANES; DIRECT FUNCTIONALIZATION; ALKYLATION; ARYLATION; ADJACENT; ETHERS; OXIDATION; ESTERS; ARENES;
D O I：
10.1039/c4qo00293h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An approach for the synthesis of isochroman derivatives via direct C(sp(3))-H bond and N-H bond coupling is described. The C-N (amine or amide) and C=N (imidate) products can be selectively achieved by controlling the amount of oxidants. Moreover, this metal-and base-free protocol is simple, easy-to-handle, and atom-economical which may have potential application in drug synthesis.
引用
收藏
页码：60 / 64
页数：5
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