Cyclic diazo compounds in the construction of spirocyclic scaffolds

被引：17

作者：

Solovyev, Igor ^{[1
]}

Eremeyeva, Maria ^{[1
]}

Zhukovsky, Daniil ^{[1
]}

Dar'in, Dmitry ^{[1
]}

Krasavin, Mikhail ^{[1
]}

机构：

[1] St Petersburg State Univ, Inst Chem, Peterhof 198504, Russia

来源：

TETRAHEDRON LETTERS | 2021年 / 62卷

基金：

俄罗斯基础研究基金会;

关键词：

Spirocyclic scaffolds; Diazo compounds; Cyclization; Multiple reactivity modes; Privileged structures for drug discovery; HIGHLY DIASTEREOSELECTIVE SYNTHESIS; CURTIUS-SCHLOTTERBECK REACTION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; RHODIUM CARBENOIDS; BETA-LACTAMS; ASYMMETRIC CYCLOPROPANATION; 1,3-DIPOLAR CYCLOADDITION; MULTICOMPONENT REACTIONS; CATALYZED-REACTIONS;

D O I：

10.1016/j.tetlet.2020.152671

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spirocycles represent an emerging class of privileged motifs for drug discovery. The versatility of diazo compounds in constructing cyclic frameworks in general makes cyclic diazo compounds a potentially highly prolific source of spirocyclic scaffolds. While the first examples of obtaining a spirocycle from a cyclic diazo compound are dated as far back as 42 years ago, there appears to be a resurgence of novel methodologies based on this premise. The present Digest Article aims to cover the literature on the subject to-date. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：14

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