Interactions of sol-gel encapsulated acyclovir with silica matrix

被引：11
|
作者：
Akimsheva, E. Yu. [1 ]
Dolinina, E. S. [1 ]
Parfenyuk, E. V. [1 ]
机构：
[1] Russian Acad Sci, GA Krestov Inst Solut Chem, 1 Acad Skaya Str, Ivanovo 153045, Russia
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 178卷 / 103-110期
关键词：
Acyclovir; Sol-gel encapsulation; Silica matrix; Interaction; UV/VIS spectroscopy; FTIR spectroscopy; ANTIVIRAL DRUG ACYCLOVIR; ULTRAVIOLET-SPECTRA; SELF-ASSOCIATION; OXAZINE DYES; SPECTROSCOPY; ADSORPTION; DELIVERY; COMPLEX; GUANINE; PURINE;
D O I：
10.1016/j.colsurfb.2019.02.052
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Encapsulation of drugs is promising strategy to improve their pharmacological and consumer properties. The functional properties of the encapsulated drug depend on interactions between the drug and capsule material. Antiviral drug acyclovir (ACV) was encapsulated in silica matrixes using sol-gel. technology. The effects of synthesis pH and the silica matrix functionalization by organic groups on the drug - silica matrix interaction were studied. The interactions were investigated using UV/VIS spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. The nature of the interactions in the obtained composites was discussed. It was found that the drug self-association in some composites can be provoked by electrostatic repulsion between the drug and the silica matrix.
引用
收藏
页码：103 / 110
页数：8
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