A preliminary study on early onset schizophrenia and bipolar disorder: large polyglutamine expansions are not involved

被引：15
|
作者：
Schurhoff, F
Stevanin, G
Trottier, Y
Bellivier, F
MourenSimeoni, MC
Brice, A
Leboyer, M
机构：
[1] HOP LA PITIE SALPETRIERE,INSERM U289,PARIS,FRANCE
[2] HOP LA PITIE SALPETRIERE,FEDERAT NEUROL,PARIS,FRANCE
[3] IGBMC,ILLKIRCH GRAFFENS,FRANCE
[4] HOP ROBERT DEBRE,SERV PEDOPSYCHIAT,F-75019 PARIS,FRANCE
[5] HOP LA PITIE SALPETRIERE,SERV PSYCHIAT ADULTE,PARIS,FRANCE
来源：
PSYCHIATRY RESEARCH | 1997年 / 72卷 / 02期
关键词：
genetics; age at onset; anticipation; triplet repeats; polyglutamine tracts;
D O I：
10.1016/S0165-1781(97)00070-X
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Genetic factors are of major aetiological importance in bipolar disorder and schizophrenia. The exact mode of inheritance is unknown, but recent arguments in favor of genetic anticipation in those two disorders suggest that dynamic mutations could be involved. Using a new antibody, we thus explored the implication of large expanded polyglutamine tracts in a sample of very early onset schizophrenic and bipolar patients. No evidence for a specific protein with polyglutamine expansion was found in either group. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：141 / 144
页数：4
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