γ-Induced thermal stability and thermal studies on timolol β-blocker

被引：6
|
作者：
Abou-Sekkina, MM [1 ]
El-Ries, MA
Molokhia, AM
Rabbie, N
Wassel, AA
机构：
[1] Tanta Univ, Fac Sci, Tanta, Egypt
[2] Natl Org Drug Control & Res, Giza, Egypt
[3] Natl Inst Stand, Radiat Dept, Giza, Egypt
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2002年 / 68卷 / 03期
关键词：
beta-blocker; HPLC; IR; gamma-radiolysis; thermal stability; timolol; UV; X-ray;
D O I：
10.1023/A:1016111126998
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Timolol drug, has been investigated by using X-ray diffraction analysis, thermogravimetry (TG), differential thermal analysis (DTA), IR, HPLC and electronic absorption spectra (UV/Vis), before and after exposure to gamma-radiation. The interaction of gamma-rays with timolol has been studied. Results obtained indicated high stability toward gamma-absorbed dose over the range 5-50 kGy.
引用
收藏
页码：1017 / 1023
页数：7
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