Study on the components of luobuma with peroxynitrite-scavenging activity

被引：47
|
作者：
Yokozawa, T
Kashiwada, Y
Hattori, M
Chung, HY
机构：
[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan
[2] Niigata Coll Pharm, Niigata 9502081, Japan
[3] Pusan Natl Univ, Coll Pharm, Gumjung Ku, Pusan 609735, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 06期
关键词：
luobuma; leaf; peroxynitrite; epigallocatechin-(4 beta-8)-epicatechin;
D O I：
10.1248/bpb.25.748
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The origin of the antioxidant activity of Luobuma aqueous extract was examined by measuring the peroxynitrite (ONOO-)-eliminating activities of fractions of this extract obtained by Sephadex LH-20 column chromatography. Three of the four fractions obtained, i.e., those excluding the H2O-eluted fraction, were found to possess ONOO--eliminating activity. These three fractions were combined and fractionated again by Sephadex LH-20 column chromatography, which yielded five fractions. Seven different compounds were isolated from two of these five fractions with high activity. Epigallocatechin-(4beta-8)-epicatechin showed the highest ONOO--eliminating activity.
引用
收藏
页码：748 / 752
页数：5
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