Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET

被引：28
|
作者：
Edison, Paul [1 ]
Brooks, David J. [2 ,3 ]
机构：
[1] Imperial Coll London, Dept Med, Neurol Imaging Unit, London, England
[2] Aarhus Univ, Dept Nucl Med, Aarhus, Denmark
[3] Univ Newcastle Tyne, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 64卷
关键词：
Alzheimer's disease; astrocytes; microglia; neurodegeneration; neuroinflammation; POSITRON-EMISSION-TOMOGRAPHY; PROTEIN; 18; KDA; PERIPHERAL BENZODIAZEPINE-RECEPTOR; MILD COGNITIVE IMPAIRMENT; MICROGLIAL ACTIVATION; RADIOLIGAND BINDING; INITIAL EVALUATION; HEALTHY HUMANS; BRAIN-INJURY; ION-CHANNEL;
D O I：
10.3233/JAD-179929
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent evidence suggests that neuroinflammation and immunity play a significant role in Alzheimer's disease and other neurodegenerative diseases. It has also been observed that, independent of the presence of aggregated proteins, neuroinflammation could be present in different neurodegenerative diseases. It has also been suggested that neuroinflammation could occur well ahead of amyloid deposition in AD. Recent genetic studies and other preclinical studies specifically point to a role of neuroinflammation and, in this review, we evaluate the evidence of neuroinflammation in the Alzheimer's disease trajectory and the different imaging modalities by which we could monitor neuroinflammation in vivo in humans.
引用
收藏
页码：S339 / S351
页数：13
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