Ergogenic and metabolic effects of oral glucocorticoid intake during repeated bouts of high-intensity exercise

被引:15
|
作者
Zorgati, Houssem [1 ]
Prieur, Fabrice [1 ]
Vergniaud, Thomas [1 ]
Cottin, Francois [1 ]
Manh-Cuong Do [1 ]
Labsy, Zakaria [1 ]
Amarantini, David [2 ]
Gagey, Olivier [1 ]
Lasne, Francoise
Collomp, Katia [1 ]
机构
[1] Univ Orleans, Univ Paris 11, Lab CIAMS, EA 4532, F-45062 Orleans, France
[2] Univ Toulouse, Lab PRISSMH, Toulouse, France
关键词
Performance; Prednisone; DHEA; Testosterone; Cytokine; SALIVA ADRENOCORTICAL HORMONES; SUBMAXIMAL EXERCISE; INFLAMMATORY MEDIATORS; RESISTANCE EXERCISE; PREDNISOLONE INTAKE; SOCCER PLAYERS; SERUM; INTERLEUKIN-6; CORTISOL; ENDURANCE;
D O I
10.1016/j.steroids.2014.04.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
All systemically administered glucocorticoids (GC) are prohibited in-competition, because of the potential ergogenic effects. Although short-term GC intake has been shown to improve performance during submaximal exercise, literature on its impact during brief intense exercise appears to be very scant. The purpose of this study was to examine the ergogenic and metabolic effects of prednisone during repeated bouts of high-intensity exercise. In a double-blind randomized protocol, ten recreational male athletes followed two 1-week treatments (Car: prednisone, 60 mg/day or Pla: placebo). At the end of each treatment, they hopped on their dominant leg for 30 s three times consecutively and then hopped until exhaustion, with intervals of 5 min of passive recovery. Blood and saliva samples were collected at rest and 3 min after each exercise bout to determine the lactate, interleukin-6, interleukin-10, TNF-alpha, DHEA and testosterone values. The absolute peak force of the dominant leg was significantly increased by Cor but only during the first 30-s hopping bout (p < 0.05), whereas time to exhaustion was not significantly changed after Car treatment vs Pla (Pla: 119.9 +/- 24.7; Car: 123.1 +/- 29.5 s). Cot intake lowered basal and end-exercise plasma interleukin-6 and saliva DHEA (p < 0.01) and increased interleukin-10 (p < 0.01), whereas no significant change was found in blood lactate and TNF-alpha or saliva testosterone between Pla and Cot. According to these data, short-term glucocorticoid intake did not improve endurance performance during repeated bouts of high-intensity exercise, despite the significant initial increase in absolute peak force and anti-inflammatory effect. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:10 / 15
页数:6
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