Clinical and Pathologic Risk Factors of Tumor Recurrence in Patients With Node-Negative Early Breast Cancer After Mastectomy

被引：12

作者：

Lin, Po-Han ^{[1
,2
,3
,4
]}

Yeh, Ming-Hsin ^{[5
]}

Liu, Liang-Chih ^{[5
]}

Chen, Chih-Jung ^{[5
]}

Tsui, Yu-Chu ^{[5
]}

Su, Chen-Hsien ^{[5
]}

Wang, Hwei-Chung ^{[5
]}

Liang, Ji-An ^{[6
]}

Chang, Hui-Wen ^{[7
]}

Wu, Hsiao-Su ^{[5
]}

Yeh, Su-Peng ^{[3
,8
]}

Li, Long-Yuan ^{[9
,10
]}

Chiu, Chang-Fang ^{[3
,8
]}

机构：

[1] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Med Genet, Taichung 40447, Taiwan

[3] China Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taichung 40447, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Med Genet, Taipei, Taiwan

[5] China Med Univ Hosp, Dept Surg, Taichung 40447, Taiwan

[6] China Med Univ Hosp, Dept Radiat Oncol, Taichung 40447, Taiwan

[7] China Med Univ Hosp, Dept Pathol, Taichung 40447, Taiwan

[8] China Med Univ, Coll Med, Taichung, Taiwan

[9] China Med Univ, Ctr Mol Med, Taichung, Taiwan

[10] China Med Univ, Grad Inst Canc Biol, Taichung, Taiwan

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2013年 / 108卷 / 06期

关键词：

node-negative; breast cancer; lymphovascular invasion; grade; radiotherapy; PERITUMORAL VASCULAR INVASION; PROGNOSTIC VALUE; POSTMASTECTOMY RADIOTHERAPY; LOCOREGIONAL RECURRENCE; ADJUVANT THERAPY; ST-GALLEN; FOLLOW-UP; EXPRESSION; GRADE; CYCLOPHOSPHAMIDE;

D O I：

10.1002/jso.23403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and ObjectivesPatients with node-negative breast cancer (NNBC) usually have a good prognosis, but tumor recurrence still compromises survival. In this study, we sought to identify clinical and pathologic factors that predict recurrence. MethodsA total of 716 patients who were proved with pT1-2N0M0 breast cancer between 2005 and 2009 were enrolled in this study. ResultsForty-seven of the 716 patients developed tumor recurrence during the 47.0 months of median follow-up. The significant risk factors of recurrence were lymphovascular invasion (LVI) (hazard ratio [HR]=4.60, 95% CI. 2.32-9.10) and Nottingham grade 3 (HR=4.99, 95% CI. 1.06-23.48); adjuvant radiotherapy (HR=0.35, 95% CI. 0.14-0.92) prevented tumor recurrence. Furthermore, we investigate the therapeutic impact of adjuvant chemotherapy and radiotherapy on patients with LVI and Nottingham grade 3. The adverse effect of LVI and grade 3 can be abrogated by adjuvant radiotherapy in recurrence-free survival (RFS) (LVI((+))radiotherapy((+)), no recurrence; grade 3((+))radiotherapy((+)), HR=0.82, 95% CI. 0.18-3.70). However, adjuvant chemotherapy did not. ConclusionsLVI and Nottingham grade 3 were the independent risk factors predicting tumor recurrence for patients with NNBC. Adjuvant radiotherapy might be considered in NNBC patients with these unfavorable factors to improve the RFS. J. Surg. Oncol. 2013; 108:352-357. (c) 2013 Wiley Periodicals, Inc.

引用

页码：352 / 357

页数：6

共 50 条

[1] IMPACT OF CLINICAL AND PATHOLOGIC FACTORS ON RECURRENCE OF NODE-NEGATIVE EARLY BREAST CANCER
Lin, P.
Li, L.
Yeh, M.
Liu, L.
Chen, C.
Tsui, Y.
Su, C.
Liang, J.
Wang, H.
Chiu, C.
[J]. BREAST, 2013, 22 : S52 - S52
[2] Recurrence risk in small, node-negative, early breast cancer
Nagaoka, R.
Horiguchi, J.
Takata, D.
Sato, A.
Tokiniwa, H.
Higuchi, T.
Uchida, S.
Tsuboi, M.
Kikuchi, M.
Takeyoshi, I.
[J]. BREAST, 2015, 24 : S118 - S119
[3] Association Between Breast Cancer Biological Subtype and Risk of Locoregional Recurrence A Mastectomy in Node-Negative Patients
Tseng, Y. D.
Uno, H.
Hughes, M. E.
Niland, J. C.
Wong, Y.
Theriault, R.
Marcom, P. K.
Moy, B.
Breslin, T.
Edge, S. B.
Wilson, J. L.
Punglia, R. S.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 90 : S244 - S244
[4] Risk of Recurrence and Chemotherapy Benefit for Patients With Node-Negative, Estrogen Receptor-Positive Breast Cancer: Recurrence Score Alone and Integrated With Pathologic and Clinical Factors
Tang, Gong
Cuzick, Jack
Costantino, Joseph P.
Dowsett, Mitch
Forbes, John F.
Crager, Michael
Mamounas, Eleftherios P.
Shak, Steven
Wolmark, Norman
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (33) : 4365 - 4372
[5] Close or positive margins after mastectomy in early-stage, node-negative breast cancer: The association of tumor grade with local recurrence
Hastings, J. R.
Iganej, S.
Bugoci, D. M.
Huang, C.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
[6] A risk index for early node-negative breast cancer
Boyages, J.
Taylor, R.
Chua, B.
Ung, O.
Bilous, M.
Salisbury, E.
Wilcken, N.
[J]. BRITISH JOURNAL OF SURGERY, 2006, 93 (05) : 564 - 571
[7] Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
Gamucci, T.
Vaccaro, A.
Ciancola, F.
Pizzuti, L.
Sperduti, I.
Moscetti, L.
Longo, F.
Fabbri, M. A.
Giampaolo, M. A.
Mentuccia, L.
Di Lauro, L.
Vici, P.
[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2013, 139 (05) : 853 - 860
[8] Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
T. Gamucci
A. Vaccaro
F. Ciancola
L. Pizzuti
I. Sperduti
L. Moscetti
F. Longo
M. A. Fabbri
M. A. Giampaolo
L. Mentuccia
L. Di Lauro
P. Vici
[J]. Journal of Cancer Research and Clinical Oncology, 2013, 139 : 853 - 860
[9] Recurrence risk of node-negative and ER-positive early-stage breast cancer patients by combining recurrence score, pathologic, and clinical information: A meta-analysis approach
Tang, G.
Cuzick, J.
Wale, C.
Costantino, J. P.
Crager, M.
Shak, S.
Wolmark, N.
Dowsett, M.
Forbes, J. F.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
[10] Risk Factors for Regional Recurrence in Node-Negative Breast Cancer: Implications of Regional Nodal Irradiation
Kim, S. W.
Chun, M.
Oh, Y. T., Sr.
Noh, O. K.
Cho, O.
Kang, S. H.
Jang, H.
Jo, S.
Cho, H. S.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 99 (02): : E23 - E23

← 1 2 3 4 5 →