The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?

被引：8
|
作者：
Smolarz, Beata [1 ]
Szyllo, Krzysztof [2 ]
Romanowicz, Hanna [1 ]
机构：
[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Rzgowska 281-289, PL-93338 Lodz, Poland
[2] Polish Mothers Mem Hosp Res Inst, Dept Operat Gynaecol & Oncol Gynaecol, Rzgowska 281-289, PL-93338 Lodz, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 21期
关键词：
endometriosis; genes; ESR2; polymorphism; expression; ESTROGEN-RECEPTOR-BETA; GENOME-WIDE ASSOCIATION; BREAST-CANCER RISK; QUALITY-OF-LIFE; AROMATASE GENE; POSSIBLE INVOLVEMENT; ALPHA EXPRESSION; GRANULOSA-CELLS; ER-BETA; POLYMORPHISMS;
D O I：
10.3390/ijms21218235
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention has been focused on the genetic mechanisms that may be of particular significance for the increased incidence rates of endometriosis. According to most recent studies, ESR2 and CYP19A1 genes may account for the potential risk factors of infertility associated with endometriosis. The paper presents a thorough review of the latest reports and data concerning the genetic background of the risk for endometriosis development.
引用
收藏
页码：1 / 22
页数：22
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