High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial

被引：24

作者：

Purcell, Robert ^{[1
]}

Latham, Sally H. ^{[1
]}

Botham, Kathleen M. ^{[1
]}

Hall, Wendy L. ^{[2
]}

Wheeler-Jones, Caroline P. D. ^{[1
]}

机构：

[1] Kings Coll London, Royal Vet Coll, London SE1 9NH, England

[2] Kings Coll London, Diabet & Nutr Sci Div, London SE1 9NH, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2014年 / 100卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; HEALTHY-MEN; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; FISH-OIL; OMEGA-3-FATTY-ACID SUPPLEMENTATION; DOCOSAHEXAENOIC ACID; ARTERIAL STIFFNESS;

D O I：

10.3945/ajcn.114.091223

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation has beneficial cardiovascular effects, but postprandial influences of these individual fatty acids are unclear. Objectives: The primary objective was to determine the vascular effects of EPA + DHA compared with DHA only during postprandial lipemia relative to control high oleic acid meals; the secondary objective was to characterize the effects of linoleic acid enriched high-fat meals relative to the control meal. Design: We conducted a randomized, controlled, double-blind crossover trial of 4 high-fat (75-g) meals containing I) high oleic acid sunflower oil (HOS; control), 2) HOS + fish oil (FO; 5 g EPA and DHA), 3) HOS + algal oil (AO; 5 g DHA), and 4) high linoleic acid sunflower oil (HLS) in 16 healthy men (aged 35-70 y) with higher than optimal fasting triacylglycerol concentrations (mean +/- SD triacylglycerol, 1.9 +/- 0.5 mmol/L). Results: Elevations in triacylglycerol concentration relative to baseline were slightly reduced after FO and HLS compared with the HOS control (P < 0.05). The characteristic decrease from baseline in plasma nonesterified fatty acids after a mixed meal was inhibited after AO (Delta 0-3 h, P < 0.05). HLS increased the augmentation index compared with the other test meals, (P < 0.05), although the digital volume pulse reflection index was not significantly different. Plasma 8-isoprostane F-2 alpha analysis revealed opposing effects of FO (increased) and AO (reduced) compared with the control (P < 0.05). No differences in nitric oxide metabolites were observed. Conclusions: These data show differential postprandial 8-isoprostane F-2 alpha responses to high-fat meals containing EPA + DHA-rich fish oil compared with DHA-rich AO, but these differences were not associated with consistent effects on postprandial vascular function or lipemia. More detailed analyses of polyunsaturated fatty acid-derived lipid mediators are required to determine possible divergent functional effects of single meals rich in either DHA or EPA. This trial was registered at clinicaltrials.gov as NCT01618071.

引用

页码：1019 / 1028

页数：10