Synthesis of propane-2,3-diol combinatorial monomers

被引：27
|
作者：
Acevedo, OL
Andrews, RS
机构：
[1] Isis Pharmaceutical, Carlsbad, CA 92008
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期
关键词：
D O I：
10.1016/0040-4039(96)00745-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroarylpropane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis. (C) 1996 Elsevier Science Ltd
引用
收藏
页码：3931 / 3934
页数：4
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