Stochastic model of tumor-induced angiogenesis: Ensemble averages and deterministic equations

被引:18
|
作者
Terragni, F. [1 ]
Carretero, M. [1 ]
Capasso, V. [2 ]
Bonilla, L. L. [1 ]
机构
[1] Univ Carlos III Madrid, G Millan Inst, Fluid Dynam Nanosci & Ind Math, Leganes 28911, Spain
[2] Univ Milan, ADAMSS, I-20133 Milan, Italy
关键词
SPROUTING ANGIOGENESIS; ENDOTHELIAL-CELLS; GROWTH-FACTOR; MECHANISMS; SIMULATIONS; DISEASE;
D O I
10.1103/PhysRevE.93.022413
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
A recent conceptual model of tumor-driven angiogenesis including branching, elongation, and anastomosis of blood vessels captures some of the intrinsic multiscale structures of this complex system, yet allowing one to extract a deterministic integro-partial-differential description of the vessel tip density [Phys. Rev. E 90, 062716 (2014)]. Here we solve the stochastic model, show that ensemble averages over many realizations correspond to the deterministic equations, and fit the anastomosis rate coefficient so that the total number of vessel tips evolves similarly in the deterministic and ensemble-averaged stochastic descriptions.
引用
收藏
页数:11
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