Aqueous phase mono-protection of amines and amino acids as N-benzyloxycarbonyl derivatives in the presence of β-cyclodextrin

被引：23

作者：

Kumar, V. Pavan ^{[1
]}

Reddy, M. Somi ^{[1
]}

Narender, M. ^{[1
]}

Surendra, K. ^{[1
]}

Nageswar, Y. V. D. ^{[1
]}

Rao, K. Rama ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 36期

关键词：

amino acids; amines; Cbz-Cl; beta-cyclodextrin; buffer; water;

D O I：

10.1016/j.tetlet.2006.06.162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and selective protection of amines/amino acids with Cbz-Cl has been achieved in aqueous phase with catalytic amounts of beta-cyclodextrin in high yields at room temperature. This reaction proceeds without the formation of any by-products and has advantages over existing methods. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6393 / 6396

页数：4

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