Effect of transforming growth factor-beta on fibroblasts in ossification of the posterior longitudinal ligament

被引：0
|
作者：
Inaba, K [1 ]
Matsunaga, S [1 ]
Ishidou, Y [1 ]
Imamura, T [1 ]
Yoshida, H [1 ]
机构：
[1] KAGOSHIMA UNIV,FAC MED,DEPT PATHOL 1,KAGOSHIMA 890,JAPAN
来源：
IN VIVO | 1996年 / 10卷 / 04期
关键词：
Transforming growth factor-beta; ossification of the posterior longitudinal ligament (OPLL);
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the immunohistochemical localization of TGF-beta in the ligament tissue of patients with ossification of the posterior longitudinal ligament(OPLL), and the effects of TGF-beta on cultured cells derive from the spinal ligament of patients with OPLL. ALP activity in the cultured cells was also examined. TGF-beta was present in the ossified matrix and in the chondrocytes in cartilaginous areas adjacent to OPLL. ALP activity was high in the cultured cells of OPLL patients. Exogenous TGF-beta inhibited proliferation in the OPLL cells but promoted proliferation in control cells. These results suggest that the spinal ligaments of OPLL patients have an osteogenetic predisposition and that TGF-beta may play a role in the ossification.
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页码：445 / 449
页数：5
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