Exercise for women with or at risk for breast cancer-related lymphedema

Breast cancer accounts for approximately one third of all cancers diagnosed in American women. In 2005, it was estimated that 211,240 women would be diagnosed with invasive breast cancer in the United States and 58,490 would be diagnosed with in situ breast cancer.(1) Although advancements in technology have led to early detection and a higher survival rate,2 approximately 40,410 US women were expected to die from this disease in 2005(1). Many women experience secondary complications of the disease in 2005(1). Many women experience secondary complications of the disease and its treatments, including decreased quality of life (QOL), weight gain, sleep disturbances,poor body image, fatigue,3 increased risk for osteoporosis, cardiovascular disease, premature menopause, and lymphedema.(4). Breast cancer is commonly treated by surgery, chemotherapy, or radiation. Axillary dissection or radiation can result in lymphedema due to obstruction, trauma, and inflammation of the lymphatic system.(5) Lymphedema has been defined as an abnormal accumulation of protein-rich fluid,(4 5) edema, and chronic inflammations(5,7) and can elicit pain, tightness, and heaviness in the upper extremity (UE), as well as lead to recurrent skin infections.(8) Lymphedema is classified into 3 stages based on severity. Stage I lymphedema is spontaneously reversible(9) and typically involves pitting edema, an increase in UE girth, and heaviness.(8) Stage II is marked by a spongy consistency of the tissue without signs of pitting edema. Tissue fibrosis causes limbs to harden and increase in size. Stage III, lymphostatic elephantiasis, is the most advanced. stage but is rarely seen following breast cancer treatment.(9).