Synthesis and Antiproliferative Evaluation of Chenodeoxycholic Acid Containing-Nitrogen Derivatives

被引：2

作者：

Huang, Yanmin ^{[1
]}

Yao, Qiucui ^{[2
]}

Liu, Zhiping ^{[1
]}

Gan, Chunfang ^{[1
]}

Zheng, Jiahua ^{[1
]}

Sheng, Haibing ^{[1
]}

Shi, Haishing ^{[3
]}

Cui, Jianguo ^{[1
,3
]}

机构：

[1] Guangxi Teachers Educ Univ, Chem & Mat Sci Coll, Nanning 53001, Peoples R China

[2] Guangxi Teachers Educ Univ, Key Lab Beibu GulfEnvironm Change & Resources Uti, Nanning 530219, Peoples R China

[3] Qinzhou Univ, Guangxi Coll & Univ Key Lab Beibu Gulf Oil & Nat, Qinzhou 535000, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 35卷 / 10期

基金：

中国国家自然科学基金;

关键词：

chenodeoxycholic acid; nitrogen-containing compounds; antiproliferative activity; bioactivity; CYTOTOXIC AGENTS STRUCTURE/ACTIVITY; LACTAM DERIVATIVES; STEROIDAL OXIMES; INDUCE APOPTOSIS;

D O I：

10.6023/cjoc201503048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chenodeoxycholic acid nitrogen-containing derivatives display anti-tumor activities and induce apoptosis of the cacer cells. Some chenodeoxycholic acid derivatives possessing various nitrogen-containing substituent in 3- or 7-position of steroidal nucleus were designed and synthesized using chenodeoxycholic acid as starting materials. Their structures were characterized by IR, NMR and MS. Antiproliferative activities of the compounds were assayed against human gastric cancer cells (SGC-7901), human hepatic cancer (Bel-7404) and prostate cancer cell (PC-3) by MTT method. The results showed that some nitrogen-containing derivatives of chenodeoxycholic acid had better antiproliferative activities against Bel-7404 and PC-3 cells.

引用

页码：2168 / 2175

页数：8

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