How obesity causes diabetes in Zucker diabetic fatty rats

被引：104
|
作者：
Unger, RH
机构：
[1] Center for Diabetes Research, Univ. of Texas Southwestern Med. C., Dallas
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1997年 / 8卷 / 07期
关键词：
D O I：
10.1016/S1043-2760(97)00094-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, ave I reviewed. In ZDF rats, a mutation in the leptin receptor OB-R, is associated with leptin resistance obesity and increased fat content of islets, Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs beta-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production. (C) 1997, Elsevier Science Inc.
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页码：276 / 282
页数：7
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