Genotypic Prediction of Human Immunodeficiency Virus Type 1 CRF02-AG Tropism

被引：43

作者：

Raymond, Stephanie ^{[1
,2
,3
]}

Delobel, Pierre ^{[2
,4
]}

Mavigner, Maud ^{[2
]}

Cazabat, Michelle ^{[1
,2
]}

Souyris, Corinne ^{[1
,2
]}

Encinas, Stephanie ^{[1
,2
]}

Sandres-Saune, Karine ^{[1
,2
,3
]}

Pasquier, Christophe ^{[1
,2
,3
]}

Marchou, Bruno ^{[3
,4
]}

Massip, Patrice ^{[3
,4
]}

Izopet, Jacques ^{[1
,2
,3
]}

机构：

[1] CHU Toulouse, Hop Purpan, Virol Lab, F-31300 Toulouse, France

[2] INSERM, U563, F-31300 Toulouse, France

[3] Univ Toulouse 3, Fac Med Toulouse Purpan, F-31300 Toulouse, France

[4] CHU Toulouse, Hop Purpan, Serv Malad Infect & Trop, F-31300 Toulouse, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 07期

关键词：

CORECEPTOR USAGE; V3; SEQUENCES; PHENOTYPE; MOLECULE; CAMEROON; SUBTYPES; DISEASE; DOMAIN; ENV;

D O I：

10.1128/JCM.02439-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.

引用

页码：2292 / 2294

页数：3

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