Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease

被引：8
|
作者：
Anderson, JL [1 ]
Horne, BD
Carlquist, JF
Bair, TL
Habashi, J
Hart, NI
Jones, SK
Muhlestein, JB
机构：
[1] Latter Day St Hosp, Div Cardiol, Dept Cardiovasc, Salt Lake City, UT 84143 USA
[2] Univ Utah, Sch Med, Salt Lake City, UT USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 05期
关键词：
D O I：
10.1016/S0002-9149(02)02531-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Because folic acid may reduce homocysteine (HCY) plasma levels, a new risk factor for coronary artery disease, we tested whether a Food and Drug Administration (FDA) mandate for folic acid fortification of foods would affect plasma HCY among 2,755 subjects studied angiographically over 4 years and at high risk of incident coronary events. Plasma HCY decreased by approximate to2 mumol/L, and the percentage of patients with "high-risk" HCY decreased by 1/3 in temporal association with implementation of the FDA rule.
引用
收藏
页码：536 / +
页数：5
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