Ruthenium-Catalyzed Cyclization of Ketoxime Acetates with DMF for Synthesis of Symmetrical Pyridines

被引：151
|
作者：
Zhao, Mi-Na [1 ]
Hui, Rong-Rong [1 ]
Ren, Zhi-Hui [1 ]
Wang, Yao-Yu [1 ]
Guan, Zheng-Hui [1 ]
机构：
[1] NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Dept Chem & Mat Sci, Xian 710069, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; SUBSTITUTED PYRIDINES; FUNCTIONALIZED PYRIDINES; REGIOSELECTIVE SYNTHESIS; AMMONIUM IODIDE; DERIVATIVES; ALKYNES; CYANATION; N; N-DIMETHYLFORMAMIDE; ARYNES;
D O I：
10.1021/ol501183z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel ruthenium-catalyzed cyclization of ketoxime carboxylates with N,N-dimethylformamide (DMF) for the synthesis of tetrasubstituted symmetrical pyridines has been developed. A methyl carbon on DMF performed as a source of a one carbon synthon. And NaHSO3 plays a role in the reaction.
引用
收藏
页码：3082 / 3085
页数：4
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