ROR1-CAR T-CELLS AS NOVEL TREATMENT STRATEGY FOR ANAPLASTIC THYROID CARCINOMA

被引：0
|
作者：
Chernyakov, D. [1 ]
Skorobohatko, O. [1 ]
Edemir, B. [2 ]
Nerger, K. [1 ]
Mueller, T. [1 ]
Binder, M. [1 ]
Trojanowicz, B. [1 ]
Lorenz, K. [1 ]
Huettelmaier, S. [3 ]
Alb, M. [1 ]
Hudecek, M. [4 ]
Dierks, C. [1 ]
机构：
[1] Univ Klinikum Halle Saale, Halle, Saale, Germany
[2] Univ Witten Herdecke, Witten, Germany
[3] Inst Mol Med, Halle, Saale, Germany
[4] Univ Klinikum Wurzburg, Wurzburg, Germany
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷
关键词：
D O I：
10.1136/jitc-2022-ITOC9.41
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P06.01
引用
收藏
页码：A22 / A23
页数：2
相关论文
共 50 条
  • [1] Design and structural modification of ROR1 CAR T-cells as a treatment for CLL
    Davies, David Marc
    Moscosso, Solange Parades
    Gohil, Satyen
    Pule, Martin
    Nathwani, Amit
    [J]. HUMAN GENE THERAPY, 2014, 25 (05) : A17 - A18
  • [2] Characterization of the surface marker ROR1 as a potential target of CAR-T cell therapy in anaplastic thyroid carcinoma
    Skorobohatko, O.
    Chernyakov, D.
    Braeuer-Hartmann, D.
    Mueller, T.
    Wehde, J.
    Trojanowicz, B.
    Alb, M.
    Hudecek, M.
    Lorenz, K.
    Dierks, C.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 198 - 198
  • [3] Characterization of the Surface Marker ROR1 as a potential Target of CAR-T Cell Therapy in anaplastic Thyroid Carcinoma
    Skorobohatko, O.
    Chernyakov, D.
    Edemir, B.
    Nerger, K.
    Binder, M.
    Trojanowicz, B.
    Lorenz, K.
    Huttelmaier, S.
    Alb, M.
    Hudecek, M.
    Dierks, C.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 155 - 156
  • [4] Generation and preclinical evaluation of a novel ROR1-specific CAR T-cells against chronic lymphocytic leukemia
    Hasan, Md Kamrul
    Oh, Christopher
    Girgis, Christina
    Widhopf, George
    Prussak, Charles
    Kipps, Thomas
    [J]. LEUKEMIA & LYMPHOMA, 2023, 64 : S195 - S195
  • [5] A phase I study of adoptive immunotherapy for advanced ROR1+malignancies with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)
    Specht, Jennifer M.
    Lee, Sylvia
    Turtle, Cameron J.
    Berger, Carolina
    Baladrishnan, Ashwini
    Srivastava, Shivani
    Voillet, Valentin
    Veatch, Josh
    Gooley, Ted
    Mullane, Erin
    Chaney, Colette
    Rader, Christoph
    Pierce, Robert H.
    Gottardo, Raphael
    Maloney, David G.
    Riddell, Stanley R.
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [6] Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1
    Tran, Tri Minh
    Thakuri, Bal Krishna Chand
    Nurmukhambetova, Saule
    Lee, Jia-Jye
    Hu, Peirong
    Tran, Ngoc Q.
    Steimle, Brittany
    Dash, Pradyot
    Schneider, Dina
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 12 (04)
  • [7] The anti-tumor function of ROR1-CAR modified T-cells against triple-negative breast cancer is enhanced by shielding from immunosuppressive TGF-β
    Stueber, T.
    Wallstabe, L.
    Rydzek, J.
    Nerreter, T.
    Woeckel, A.
    Einsele, H.
    Wischhusen, J.
    Hudecek, M.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 7 - 7
  • [8] ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models
    Wallstabe, Lars
    Goettlich, Claudia
    Nelke, Lena C.
    Kuehnemundt, Johanna
    Schwarz, Thomas
    Nerreter, Thomas
    Einsele, Hermann
    Walles, Heike
    Dandekar, Gudrun
    Nietzer, Sarah L.
    Hudecek, Michael
    [J]. JCI INSIGHT, 2019, 4 (18)
  • [9] Clinical-grade Manufacturing of ROR1 CAR T-cells using a Novel virus-free Protocol
    Mestermann, Katrin
    Eichler, Marie
    Machwirth, Markus
    Kebbel, Kati
    Koehl, Ulrike
    Einsele, Hermann
    Mueller, Claudia
    Lehmann, Joerg
    Rasko, Tamas
    Lundberg, Felix
    Izsvak, Zsuzsanna
    Schmiedeknecht, Gerno
    Hudecek, Michael
    [J]. BONE MARROW TRANSPLANTATION, 2020, 55 (SUPPL 1) : 261 - 262
  • [10] Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma
    Mizutani, K
    Onda, M
    Asaka, S
    Akaishi, J
    Miyamoto, S
    Yoshida, A
    Nagahama, M
    Ito, K
    Emi, M
    [J]. CANCER, 2005, 103 (09) : 1785 - 1790
12345