An improved oil emulsion synthesis method for large, porous zirconia particles for packed- or fluidized-bed protein chromatography

被引：7

作者：

Robichaud, MJ

Sathyagal, AN

Carr, PW

Flickinger, MC

机构：

[1] UNIV MINNESOTA,BIOL PROC TECHNOL INST,ST PAUL,MN 55108

[2] UNIV MINNESOTA,DEPT BIOCHEM,ST PAUL,MN 55108

[3] UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455

[4] UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455

来源：

SEPARATION SCIENCE AND TECHNOLOGY | 1997年 / 32卷 / 15期

关键词：

D O I：

10.1080/01496399708000785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A previously reported oil emulsion technique for the synthesis of large, porous zirconia particles has been modified to overcome problems of nonreproducibility, formation of non-spherical or broken particles, and low yield of chromatographically useful particles. The improved technique described here uses a concentrated sol and an in-line mixer to successfully solve these problems. The results indicate that the stirring rate used to maintain the emulsion during drying has a strong effect on the final particle size.

引用

页码：2547 / 2559

页数：13