Design and synthesis of three carbon bridged 2,4-diaminopyrrolo [2,3-D] pyrimidines as nonclassical DHFR inhibitors

被引：0
|
作者：
Gangjee, A
Ye, ZQ
机构：
[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Div Med Chem, Pittsburgh, PA 15282 USA
[2] Indiana Univ, Dept Pharmacol & Toxicol, Bloomington, IN 47405 USA
[3] Tufts Univ, Sch Med, Medford, MA 02155 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 223卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
191-MEDI
引用
收藏
页码：B130 / B130
页数：1
相关论文
共 50 条
  • [1] Synthesis of three carbon atom bridged 2,4-diaminopyrrolo[2,3-d]-pyrimidines as nonclassical dihydrofolate reductase inhibitors
    Gangjee, A
    Ye, ZQ
    Queener, SF
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (06) : 1127 - 1133
  • [2] QSAR analysis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminopyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors
    Jain, P
    Soni, LK
    Gupta, AK
    Kashkedikar, SG
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2005, 42 (05): : 315 - 320
  • [3] SYNTHESIS OF NOVEL 2,4-DIAMINOPYRROLO[2,3-D]PYRIMIDINES WITH ANTIOXIDANT, NEUROPROTECTIVE, AND ANTIASTHMA ACTIVITY
    BUNDY, GL
    AYER, DE
    BANITT, LS
    BELONGA, KL
    MIZSAK, SA
    PALMER, JR
    TUSTIN, JM
    CHIN, JE
    HALL, ED
    LINSEMAN, KL
    RICHARDS, IM
    SCHERCH, HM
    SUN, FF
    YONKERS, PA
    LARSON, PG
    LIN, JM
    PADBURY, GE
    AARON, CS
    MAYO, JK
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (21) : 4161 - 4163
  • [4] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL TETRACYCLIC 2,4-DIAMINOPYRROLO[2,3-D]PYRIMIDINES AS ANTIFOLATES
    GANGJEE, A
    CHEN, L
    QUEENER, SF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 84 - MEDI
  • [5] 2,4-diaminopyrrolo-[2,3-d]pyrimidines
    Lloyd, AW
    DRUG DISCOVERY TODAY, 1996, 1 (02) : 83 - 83
  • [6] Synthesis of 2,4-diaminopyrrolo[2,3-d]pyrimidines via thermal fischer indolization.: Pyrazole formation with ytterbium triflate catalysis
    Bundy, GL
    Schwartz, TM
    Palmer, JR
    Banitt, LS
    Watt, W
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (06) : 1471 - 1477
  • [7] 2,4-diaminopyrrolo[2,3-d]pyrimidines: Novel heterocyclic antioxidants as potential agents for the treatment of chronic neurodegenerative disorders.
    Bundy, GL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 209 - MEDI
  • [8] Synthesis of new 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase
    Rosowsky, A
    Chen, H
    Fu, HM
    Queener, SF
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (01) : 59 - 67
  • [9] Unusual dihydrazone formation in the Fischer-indole cyclization.: The synthesis of novel nonclassical annulated 2,4-diaminopyrrolo[2,3-d]pyrimidine antifolates
    Gangjee, A
    Chen, LH
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 36 (02) : 441 - 444
  • [10] Design and synthesis of nonclassical 2,4-diamino-6-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
    Gangjee, A
    Yu, JM
    Queener, SF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U551 - U551
12345