Pro-tumorigenic AMPK in glioblastoma

被引：7
|
作者：
Leli, Nektaria Maria [1 ]
Koumenis, Constantinos [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA
来源：
NATURE CELL BIOLOGY | 2018年 / 20卷 / 07期
关键词：
CANCER; REGULATOR; GROWTH;
D O I：
10.1038/s41556-018-0129-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.
引用
收藏
页码：736 / 737
页数：2
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