Cytotoxic Biscembranes from the Soft Coral Sarcophyton glaucum

被引：21

作者：

Iwagawa, Tetsuo ^{[1
]}

Hashimoto, Kanta ^{[1
]}

Yokogawa, Yukiko ^{[1
]}

Okamura, Hiroaki ^{[1
]}

Nakatani, Munehiro ^{[1
]}

Doe, Matsumi ^{[2
]}

Morimoto, Yoshiki ^{[2
]}

Takemura, Kaoru ^{[3
]}

机构：

[1] Kagoshima Univ, Fac Sci, Dept Chem & Biosci, Kagoshima 8900065, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Chem, Osaka 5588585, Japan

[3] Sankei Kagaku Co Ltd, Kagoshima 8910122, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 05期

关键词：

PROBABLE BIOGENETIC PRECURSOR; TORTUOSUM; CEMBRANOIDS; SKELETON;

D O I：

10.1021/np8003485

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new tetracyclic biscembranes (1-7) have been isolated from the soft coral Sarcophyton glaucum. Four (1-4) may be formed biogenetically by a Diels-Alder reaction of Delta(4(5)) and Delta(8(9)) geometrical isomers of methyl sarcoate and Delta(21(34),) (35(36)) dienes, including two with a tetrahydrofuran ring between C-27 and C-30 (3, 4), and three biscembranes (5-7) are probably derived from methyl sarcoate isomers with Delta(1(14),) (4(5), 8(9)) and a cembrane diene. Their structures were established on the basis of spectroscopic methods. Six of them (1-5, 7) exhibited weak cytotoxic activity against proliferation of human promyelocytic leukemia cells (HL-60).

引用

页码：946 / 949

页数：4

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