The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

被引：5

作者：

Ribera, Jordi ^{[1
]}

Granada, Isabel ^{[1
,2
]}

Morgades, Mireia ^{[1
,2
]}

Vives, Susana ^{[1
,2
]}

Genesca, Eulalia ^{[1
]}

Gonzalez, Celia ^{[1
]}

Nomdedeu, Josep ^{[3
]}

Escoda, Lourdes ^{[4
]}

Montesinos, Pau ^{[5
]}

Mercadal, Santiago ^{[6
]}

Coll, Rosa ^{[7
]}

Gonzalez-Campos, Jose ^{[8
]}

Abella, Eugenia ^{[9
]}

Barba, Pere ^{[10
]}

Bermudez, Arancha ^{[11
]}

Gil, Cristina ^{[12
]}

Tormo, Mar ^{[13
]}

Pedreno, Maria ^{[14
]}

Martinez-Carballeira, Daniel ^{[15
]}

Hernandez-Rivas, Jesus-Maria ^{[16
,17
,18
]}

Orfao, Alberto ^{[16
,17
]}

Martinez-Lopez, Joaquin ^{[18
]}

Esteve, Jordi ^{[19
]}

Bravo, Pilar ^{[20
]}

Garcia-Guinon, Antoni ^{[21
]}

Deben, Guillermo ^{[22
]}

Moraleda, Jose M. ^{[23
]}

Queizan, Jose A. ^{[24
]}

Ortin, Xavier ^{[25
]}

Moreno, Maria J. ^{[26
]}

Feliu, Evarist ^{[1
,2
]}

Sole, Francesc ^{[1
]}

Ribera, Josep M. ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain

[2] Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain

[3] Hosp Santa Creu & Sant Pau, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain

[4] Hosp Joan 23, Inst Catala Oncol, Tarragona, Spain

[5] Hosp La Fe, Valencia, Spain

[6] Hospitalet Llobregat, Hosp Duran & Reynals, Inst Catala Oncol, Lhospitalet De Llobregat, Spain

[7] Hosp Josep Trueta, Inst Catala Oncol, Girona, Spain

[8] Hosp Univ Virgen Rocio, Seville, Spain

[9] Hosp Mar, Barcelona, Spain

[10] Hosp Valle De Hebron, Barcelona, Spain

[11] Hosp Marques Valdecilla, Santander, Spain

[12] Hosp Gen Alicante, Alicante, Spain

[13] Hosp Clin, Valencia, Spain

[14] Hosp Doctor Peset, Valencia, Spain

[15] Hosp Univ Cent Asturias, Oviedo, Spain

[16] Univ Salamanca, Hosp Univ Salamanca, IBMCC CSIC USAL, IBSAL, Salamanca, Spain

[17] CIBERONC, Salamanca, Spain

[18] Hosp Doce Octubre, Madrid, Spain

[19] Hosp Clin Barcelona, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain

[20] Hosp Univ Fuenlabrada Fuenlabrada, Lleida, Spain

[21] Hosp Arnau Vilanova, Lleida, Spain

[22] Hosp Juan Canalejo, La Coruna, Spain

[23] Univ Murcia, Hosp Clin Univ Virgen Arrixaca, IMIB, Murcia, Spain

[24] Hosp Gen Segovia, Segovia, Spain

[25] Hosp Verge Cinta, Tortosa, Spain

[26] Hosp Virgen Victoria, Malaga, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 186卷 / 02期

关键词：

acute lymphoblastic leukaemia; adults; hypodiploidy; prognosis; age; CHILDREN; IMPACT;

D O I：

10.1111/bjh.15887

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espanol de Tratamientos en Hematologia (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged <= 35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

引用

页码：263 / 268

页数：6

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