Serpin functions in host-pathogen interactions

被引：59

作者：

Bao, Jialing ^{[1
]}

Pan, Guoqing ^{[1
]}

Poncz, Mortimer ^{[2
,3
]}

Wei, Junhong ^{[1
]}

Ran, Maoshuang ^{[1
]}

Zhou, Zeyang ^{[1
,4
]}

机构：

[1] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing, Peoples R China

[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Div Pediat, Philadelphia, PA 19104 USA

[4] Chongqing Normal Univ, Coll Life Sci, Chongqing, Peoples R China

来源：

PEERJ | 2018年 / 6卷

基金：

中国国家自然科学基金;

关键词：

Serpin; Serine protease; Host-pathogen interaction; Infection; Inflammation; SERINE-PROTEASE INHIBITORS; MYXOMA-VIRUS SERP2; CYTOKINE RESPONSE MODIFIER; MANDUCA-SEXTA; GRANZYME-B; PROPHENOLOXIDASE ACTIVATION; ANTIMICROBIAL ACTIVITIES; PROTEINASE INHIBITION; SCHISTOSOMA-MANSONI; CRYSTAL-STRUCTURE;

D O I：

10.7717/peerj.4557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors. Early studies of serpins focused on their functions in haemostasis since modulating serine proteases activities are essential for coagulation. Additional research has revealed that serpins function in infection and inflammation, by modulating serine and cysteine proteases activities. The aim of this review is to summarize the accumulating findings and current understanding of the functions of serpins in host-pathogen interactions, serving as host defense proteins as well as pathogenic factors. We also discuss the potential crosstalk between host and pathogen serpins. We anticipate that future research will elucidate the therapeutic value of this novel target.

引用

页数：16

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