Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells

被引：108

作者：

Gilliet, M ^{[1
]}

Liu, YJ ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

HUMAN IMMUNOLOGY | 2002年 / 63卷 / 12期

关键词：

human dendritic cells; T regulatory cells; immunosuppression; IL-10;

D O I：

10.1016/S0198-8859(02)00753-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Suppression by T-regulatory (Tr) cells is essential for the induction of T-cell tolerance and the prevention of autoimmune diseases, organ rejection, and graft-versus-host disease. Increasing attention has been devoted to understand the role of dendritic cells (DC) in the control of Tr-cell differentiation. Here we review the recent evidence that cluster designation (CD)40-ligand activated plasmacytoid-derived DCs (DC2) have the ability to induce primary Tr-cell differentiation. We propose that in addition to the regulatory functions of immature myeloid DC, Tr-cell induction by DC2 represents a non-redundant mechanism for the safeguard of peripheral T-cell tolerance. DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo.

引用

页码：1149 / 1155

页数：7

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