Complexation equilibrium in a substrate-MgCl2(CaCl2)-Pd/C catalytic system and the influence of its position on asymmetric induction in hydrogenation of N-acetyl-dehydrophenylalanyl-S-proline

被引：3

作者：

Lisichkina, IN ^{[1
]}

Vinogradova, AI ^{[1
]}

Vasileva, TY ^{[1
]}

Kurkovskaya, LN ^{[1
]}

Saporovskaya, MB ^{[1
]}

Belikov, VM ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,INST ORGANOELEMENT CPDS,MOSCOW 117813,RUSSIA

来源：

RUSSIAN CHEMICAL BULLETIN | 1996年 / 45卷 / 08期

关键词：

diastereoselective hydrogenation; magnesium chloride; calcium chloride; complexation; promoters; catalysis; N-acyldehydrodipeptides; N-acyldipeptides;

D O I：

10.1007/BF01457764

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The role of Ca and Mg salts as promoters of asymmetric induction in hydrogenation of N-acetyl-dehydrophenylalanyl-S-proline in a substrate-MX(2)-Pd/C catalytic system was studied. The data of potentiometric titration, H-1 NMR spectroscopy, and the value of diastereomeric excess (de) of the resulting N-acetyl-R-phenylalanyl-S-proline indicate the complexation of the substrate with calcium and magnesium chlorides in an alcoholic solution. Ionization and equilibrium constants of the complex were determined. Excess salt shifts the equilibrium toward the complex formation, which increases de up to 70 %.

引用

页码：1862 / 1865

页数：4