Solid-Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis

被引：100
|
作者：
Cudjoe, Erasmus [1 ]
Bojko, Barbara [1 ]
de Lannoy, Ines [2 ]
Saldivia, Victor [2 ]
Pawliszyn, Janusz [1 ]
机构：
[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada
[2] InterVivo Solut, Toronto, ON, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期
关键词：
analytical methods; in vivo sampling; liquid chromatography; mass spectrometry; metabolomics;
D O I：
10.1002/anie.201304538
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two's compliment: Solid-phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and SPME detects semi hydrophobic and hydrophobic compounds, including lipids related to neurodegenerative diseases. RT=retention time. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12124 / 12126
页数：3
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