Nickel-Catalyzed α-Arylation of Zinc Enolates with Polyfluoroarenes via C-F Bond Activation under Neutral Conditions

被引：38
|
作者：
Yu, Daohong [1 ]
Wang, Chang-Sheng [2 ]
Yao, Cheng [2 ]
Shen, Qilong [1 ]
Lu, Long [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[2] Nanjing Tech Univ, Coll Sci, Nanjing 211816, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 21期
基金：
中国国家自然科学基金;
关键词：
CARBON FLUORINE BONDS; ASYMMETRIC HYDROGENATION; (NHC)PD(ALLYL)CL NHC; ORGANOZINC REAGENTS; COUPLING REACTIONS; SUZUKI-MIYAURA; SELECTIVE C; ALKYLATION; ESTERS; COMPLEXES;
D O I：
10.1021/ol502499q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first nickel-catalyzed alpha-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated a-aryl carboxylic acids and a-aryl amides that are important intermediates for drug discovery
引用
收藏
页码：5544 / 5547
页数：4
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