Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host-pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis

被引：8

作者：

Zumla, Alimuddin ^{[1
,2
,3
]}

Otchere, Isaac Darko ^{[4
]}

Mensah, Gloria Ivy ^{[4
]}

Asante-Poku, Adwoa ^{[4
]}

Gehre, Florian ^{[5
,6
]}

Maeurer, Markus ^{[7
,8
]}

Bates, Matthew ^{[1
,3
]}

Mwaba, Peter ^{[3
]}

Ntoumi, Francine ^{[9
,10
]}

Yeboah-Manu, Dorothy ^{[4
]}

机构：

[1] UCL, Div Infect & Immun, Ctr Clin Microbiol, London, England

[2] UCL Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London, England

[3] Univ Teaching Hosp, UNZA UCLMS Res & Training Program, Lusaka, Zambia

[4] Noguchi Mem Inst Med Res, Dept Bacteriol, Accra, Ghana

[5] Inst Trop Med, Mycobacterial Unit, Biomed Sci, Antwerp, Belgium

[6] Med Res Council MRC Unit, Vaccines & Immun Theme, Fajara, Gambia

[7] Karolinska Univ Hosp Huddinge, Dept Lab Med, Therapeut Immunol TIM Div, Stockholm, Sweden

[8] Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat, Stockholm, Sweden

[9] Marien Ngouabi Univ, Fac Sci Sante, Fdn Congolaise Rech Med, Brazzaville, Rep Congo

[10] Univ Tubingen, Inst Trop Med, Tubingen, Germany

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2017年 / 56卷

基金：

英国惠康基金;

关键词：

TB; Mycobacterium africanum; Mycobacterium tuberculosis complex; Host; Diagnostics; Vaccines; \Africa; EDCTP; GENETIC DIVERSITY; WEST-AFRICA; COMPLEX; GENOME; TRANSMISSION; POLYMORPHISM; LINEAGE; HUMANS; GAMBIA;

D O I：

10.1016/j.ijid.2016.12.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mycobacterium africanum comprises two phylogenetic lineages within the Mycobacterium tuberculosis complex (MTBC). M. africanum was first described and isolated in 1968 from the sputum of a Senegalese patient with pulmonary tuberculosis (TB) and it has been identified increasingly as an important cause of human TB, particularly prevalent in West Africa. The restricted geographical distribution of M. africanum, in contrast to the widespread global distribution of other species of MTBC, requires explanation. Available data indicate that M. africanum may also have important differences in transmission, pathogenesis, and host-pathogen interactions, which could affect the evaluation of new TB intervention tools (diagnostics and vaccines)-those currently in use and those under development. The unequal geographical distribution and spread of MTBC species means that individual research findings from one country or region cannot be generalized across the continent. Thus, generalizing data from previous and ongoing research studies on MTBC may be inaccurate and inappropriate. A major rethink is required regarding the design and structure of future clinical trials of new interventions. The West, Central, East, and Southern African EDCTP Networks of Excellence provide opportunities to take forward these pan-Africa studies. More investments intomolecular, epidemiological, clinical, diagnostic, and immunological studies across the African continent are required to enable further understanding of host-M. africanum interactions, leading to the development of more specific diagnostics, biomarkers, host-directed therapies, and vaccines for TB. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

引用

页码：126 / 129

页数：4