Structural organisation of the type IV secretion systems

被引：21
|
作者：
Waksman, Gabriel [1 ]
Orlova, Elena V.
机构：
[1] UCL, Inst Struct & Mol Biol, London WC1E 7HX, England
来源：
CURRENT OPINION IN MICROBIOLOGY | 2014年 / 17卷
基金：
英国惠康基金;
关键词：
DNA TRANSFER; LEGIONELLA-PNEUMOPHILA; BACTERIAL CONJUGATION; AGROBACTERIUM VIRB10; BRUCELLA-SUIS; CORE COMPLEX; PROTEIN TRWB; ATPASE; DOMAIN; IDENTIFICATION;
D O I：
10.1016/j.mib.2013.11.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Type IV secretion (14S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multiprotein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.
引用
收藏
页码：24 / 31
页数：8
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