Bright Building Blocks for Chemical Biology

被引：403
|
作者：
Lavis, Luke D. [1 ]
Raines, Ronald T. [2 ,3 ]
机构：
[1] Howard Hughes Med Inst, Ashburn, VA 20147 USA
[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
[3] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
ACS CHEMICAL BIOLOGY | 2014年 / 9卷 / 04期
关键词：
PHOTOINDUCED ELECTRON-TRANSFER; FLUORESCENT-PROBES; DESIGN STRATEGIES; ENERGY-TRANSFER; BODIPY DYES; PROTEIN; RED; MICROSCOPY; FLUOROPHORES; RHODAMINES;
D O I：
10.1021/cb500078u
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol. 2008, 3, 142-155), the extant collection of fluorescent probes is built on a modest set of "core" scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists.
引用
收藏
页码：855 / 866
页数：12
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