New chiral inhibitors of induced platelet aggregation: The enantiomeric specificity of (R)- and (S)-methyl and ethyl esters of 1-{4-[(1-hydroxycarbonyl)-ethoxy]-benzyl}-1H-1,2,3-triazole as a tool for determining their biological target

被引：0
|
作者：
Biagi, G
Giorgi, I
Livi, O
Scartoni, V
Catalani, R
Gervasi, G
机构：
[1] DIPARTIMENTO SCI FARMACEUT,I-56126 PISA,ITALY
[2] LAB BALDACCI SPA,I-56124 PISA,ITALY
来源：
FARMACO | 1996年 / 51卷 / 12期
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D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+) 3,5-dimethyl-2-(3-pyridyl)-tkiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy] -benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules.
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页码：761 / 766
页数：6
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