Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia

被引：42

作者：

Bowden, Nikola A.

Scott, Rodney J.

Tooney, Paul A.

机构：

[1] John Hunter Hosp, Hunter Med Res Inst, New Lambton Heights, NSW 2308, Australia

[2] Neruosci Inst Schizophrenia & Allied Disorders, Sydney, NSW, Australia

[3] Univ Newcastle, Sch Biomed Sci, Callaghan, NSW 2308, Australia

[4] John Hunter Hosp, Hunter Area Pathol Serv, Div Genet, Lambton Heights, NSW 2305, Australia

来源：

SCHIZOPHRENIA RESEARCH | 2007年 / 89卷 / 1-3期

关键词：

RGS4; schizophrenia; superior temporal gyrus; mRNA expression;

D O I：

10.1016/j.schres.2006.09.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

To identify altered mRNA expression of regulator of G-protein signalling 4 (RGS4) in the superior temporal gyrus (STG) in schizophrenia mRNA expression of RGS4 was measured from post-mortem STG tissue from 13 individuals with schizophrenia and 13 matched non-psychiatric controls using relative real-time PCR. Significantly decreased expression of RGS4 mRNA in the STG in schizophrenia was identified in 10 of the 13 matched pairs. Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：165 / 168

页数：4

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