2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure-activity relationships

被引：11

作者：

Gleave, Robert J. ^{[1
]}

Beswick, Paul J. ^{[1
]}

Brown, Andrew J. ^{[1
]}

Giblin, Gerard M. P. ^{[1
]}

Haslam, Carl P. ^{[1
]}

Livermore, David ^{[1
]}

Moses, Andrew ^{[1
]}

Nicholson, Neville H. ^{[1
]}

Page, Lee W. ^{[1
]}

Slingsby, Brian ^{[1
]}

Swarbrick, Martin E. ^{[1
]}

机构：

[1] GlaxoSmithKline, Neurosci Ctr Excellence Drug Discovery, Pain & Neuroexcitabil Discovery Performance Unit, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 23期

关键词：

Cannabinoid; CB2; CB1; SAR; CANNABINOID RECEPTOR; PHARMACOLOGY;

D O I：

10.1016/j.bmcl.2009.10.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6578 / 6581

页数：4

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