Update in HIV-associated lymphoma

Purpose of review Infection with human immunodeficiency virus (HIV) is associated with an increased risk of non-Hodgkin lymphoma and Hodgkin disease. This review summarizes developments within the past 18 months. Recent findings Investigators continue to demonstrate that many standard therapies similar to those used in the non-HIV-infected population may be used in the HAART era for patients infected with HIV. Biologic differences do exist, however, and not all treatments and outcomes are directly translatable. Some treatments, such as rituximab in combination with CHOP, may have unforeseen toxicity. Nonetheless, high-dose therapy does appear feasible and may offer curative therapy for those with refractory and relapsed disease. Summary HIV-infected persons appear to benefit from most, but not all standard treatments for lymphoma.