G1 cyclins protect pluripotency

被引：7
|
作者：
Arand, Julia
Sage, Julien [1 ]
机构：
[1] Stanford Univ, Med Ctr, Dept Pediat, SIM1 Bldg,265 Campus Dr, Stanford, CA 94305 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 03期
关键词：
EMBRYONIC STEM-CELLS; DIFFERENTIATION; MOUSE; CDK2;
D O I：
10.1038/ncb3480
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stern cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.
引用
收藏
页码：149 / 150
页数：2
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