Protooncogenic TLR4 induces NANOG-mediated oncogenic signaling via synergistic interaction with STAT3 pathway in experimental and clinical tumor-initiating cells

被引:0
|
作者
Chen, Chia-Lin [1 ]
Liu, Jian-Chang [1 ]
Sher, Linda [1 ]
Mishra, Lopa [2 ]
Tsukamoto, Hidekazu [1 ]
Machida, Keigo [1 ]
机构
[1] Univ So Calif, Los Angeles, CA USA
[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
10.1158/1538-7445.AM2013-4893
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4893
引用
收藏
页数:1
相关论文
共 24 条
  • [1] TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice
    Kumar, Dinesh Babu Uthaya
    Chen, Chia-Lin
    Liu, Jian-Chang
    Feldman, Douglas E.
    Sher, Linda S.
    French, Samuel
    DiNorcia, Joseph
    French, Samuel W.
    Naini, Bita V.
    Junrungsee, Sunhawit
    Agopian, Vatche Garen
    Zarrinpar, Ali
    Machida, Keigo
    GASTROENTEROLOGY, 2016, 150 (03) : 707 - 719
  • [2] Protooncogenic TLR4 generates NANOG-dependent tumor-initiating stem-like cells through LIN28-Let7 pathway in experimental and clinical carcinogenesis
    Machida, Keigo
    Chen, Chia-Lin
    Liu, Jian-Chang
    Sher, Linda
    Mishra, Lopa
    Tsukamoto, Hidekazu
    CANCER RESEARCH, 2012, 72
  • [3] LIN28-Let7 pathway induces the protooncogene TLR4 and generates NANOG-dependent tumor-initiating stem-like cells in experimental and clinical carcinogenesis
    Machida, Keigo
    Chen, Chia-Lin
    Liu, Jian-Chang
    Sher, Linda S.
    Mishra, Lopa
    Tsukamoto, Hidekazu
    HEPATOLOGY, 2012, 56 : 277A - 278A
  • [4] Liver progenitor cells as potential target of TLR4 oncogenic signaling to generate tumor-initiating stem-like cells
    Chen, Chia-Lin
    Tsukamoto, Hidekazu
    Liu, Jian-Chang
    Sher, Linda S.
    Petrovic, Lydia M.
    Machida, Keigo
    HEPATOLOGY, 2013, 58 : 1008A - 1008A
  • [5] TLR4 IS A PROTO-ONCOGENE WHICH GENERATES NANOG-DEPENDENT TUMOR-INITIATING STEM-LIKE CELLS IN EXPERIMENTAL AND CLINICAL HCC
    Machida, Keigo
    Chen, Chia-Lin
    Liu, Jian-Chang
    Sher, Linda S.
    Mishra, Lopa
    French, Samuel W.
    Tsukamoto, Hidekazu
    HEPATOLOGY, 2011, 54 : 447A - 447A
  • [6] TLR4 IS A PROTOONCOGENE WHICH GENERATES NANOG-DEPENDENT TUMOR-INITIATING STEM-LIKE CELLS IN EXPERIMENTAL AND CLINICAL HCC ASSOCIATED WITH ALCOHOL
    Machida, K.
    Chen, C. L.
    Liu, J. C.
    Sher, L.
    Mishra, L.
    French, S.
    Tsukamoto, H.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2012, 36 : 35A - 35A
  • [7] Fraxetin suppresses the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the TLR4/STAT3 signaling pathway
    Xu, Ruhu
    Ruan, Yingdan
    Zhang, Lan
    Gu, Yating
    Liu, Mingming
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023, 45 (03) : 287 - 294
  • [8] M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
    Yao, Rong-Rong
    Li, Jing-Huan
    Zhang, Rui
    Chen, Rong-Xin
    Wang, Yan-Hong
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2018, 16
  • [9] M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
    Rong-Rong Yao
    Jing-Huan Li
    Rui Zhang
    Rong-Xin Chen
    Yan-Hong Wang
    World Journal of Surgical Oncology, 16
  • [10] Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling
    Segatto, Ilenia
    Berton, Stefania
    Sonego, Maura
    Massarut, Samuele
    Perin, Tiziana
    Piccoli, Erica
    Colombatti, Alfonso
    Vecchione, Andrea
    Baldassarre, Gustavo
    Belletti, Barbara
    ONCOTARGET, 2014, 5 (15): : 6267 - 6279