Densitometric determination of omeprazole, pantoprazole, and their impurities in pharmaceuticals

被引：32
|
作者：
Agbaba, D
Novovic, D
Karljikovic-Rajic, K
Marinkovic, V
机构：
[1] Univ Belgrade, Fac Pharm, Inst Pharmaceut Chem & Drug Anal, YU-11000 Belgrade, Serbia
[2] Univ Belgrade, Fac Pharm, Inst Analyt Chem, YU-11000 Belgrade, Serbia
[3] Zdravljc Pharmaceut & Chem Ind, Qual Control Sector, YU-16000 Leskovac, Serbia
来源：
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2004年 / 17卷 / 03期
关键词：
planar chromatography; omeprazole; pantoprazole; impurities; pharmaceutical preparations;
D O I：
10.1556/JPC.17.2004.3.2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and N-methylpantoprazole, by HPTLC. The mobile phase chloroform-2-propanol-25% ammonia-acetonitrile, 10.8 + 1.2 + 0.3 + 4 (v/v), enables good resolution of large excesses of the drugs from the possible impurities. Regression coefficients (r > 0.998), recovery (90.7-120.0%), and detection limit (0.025-0.05%) were validated and found to be satisfactory. The methods is convenient for quantitative analysis and purity control of the compounds.
引用
收藏
页码：169 / 172
页数：4
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