The subunit selective actions of the anaesthetic etomidate at human recombinant GABA(A) receptors are determined by a single amino acid

被引：0
|
作者：
Belelli, D
HillVenning, C
Peters, JA
Lambert, JJ
Wafford, KA
Whiting, PJ
机构：
[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PHARMACOL & CLIN PHARMACOL,INST NEUROSCI,DUNDEE DD1 9SY,SCOTLAND
[2] MERCK SHARP & DOHME LTD,CTR RES NEUROSCI,TERLINGS PK CM20 2QR,ESSEX,ENGLAND
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1996年 / 119卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：P296 / P296
页数：1
相关论文
共 50 条
  • [1] Electrophysiological actions of GABA and clomethiazole on human recombinant GABAA receptors
    Nelson, RM
    Green, AR
    Hainsworth, AH
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134
  • [2] Etomidate action is dependent on a specific amino acid in the beta subunit of the GABA(A) receptor complex
    Moody, E
    Knauer, S
    Skolnick, P
    [J]. ANESTHESIOLOGY, 1997, 87 (03) : A705 - A705
  • [3] Single amino acid residues in transmembrane regions 2 and 3 of the GABAA receptor β3 subunit govern the actions of etomidate
    Ling, ATY
    Pau, D
    Weir, CJ
    Wildsmith, JAW
    Lambert, JJ
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2004, 92 (02) : 310 - 310
  • [4] Complementary regulation of anaesthetic activation of human (α6β3γ2L) and Drosophila (RDL) GABA receptors by a single amino acid residue
    Pistis, M
    Belelli, D
    McGurk, K
    Peters, JA
    Lambert, JJ
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1999, 515 (01): : 3 - 18
  • [5] Decreased agonist sensitivity of human GABA(A) receptors by an amino acid variant, isoleucine to valine, in the alpha(1) subunit
    WesthHansen, SE
    Rasmussen, PB
    Hastrup, S
    Nabekura, J
    Noguchi, K
    Akaike, N
    Witt, MR
    Nielsen, M
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 329 (2-3) : 253 - 257
  • [6] ACTIONS OF THE GENERAL ANESTHETIC PROPOFOL ON RECOMBINANT HUMAN GABA(A) RECEPTORS - INFLUENCE OF RECEPTOR SUBUNITS
    SANNA, E
    MASCIA, MP
    KLEIN, RL
    WHITING, PJ
    BIGGIO, G
    HARRIS, RA
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1995, 274 (01): : 353 - 360
  • [7] Critical amino acid residues for the allosteric actions of isoflurane and enflurane in the human GABA(A) receptor
    Harrison, NL
    Mihic, SJ
    Ye, Q
    Koltchine, V
    Finn, S
    Krasowski, M
    Wick, M
    Harris, RA
    [J]. ANESTHESIOLOGY, 1997, 87 (03) : A703 - A703
  • [8] A single amino acid in the second transmembrane domain of GABA ρ receptors regulates channel conductance
    Zhu, Yujie
    Ripps, Harris
    Qian, Haohua
    [J]. NEUROSCIENCE LETTERS, 2007, 418 (02) : 205 - 209
  • [9] Felbamate is a subunit selective modulator of recombinant γ-aminobutyric acid type A receptors expressed in Xenopus oocytes
    Simeone, Timothy A.
    Otto, James F.
    Wilcox, Karen S.
    White, H. Steve
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 552 (1-3) : 31 - 35
  • [10] Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABAC receptors
    Hinton, Tina
    Chebib, Mary
    Johnston, Graham A. R.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (01) : 402 - 404
12345