Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds

Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)(2)SbCI (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)(2)Sb](2)O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as H-1 NMR, C-13 NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis. (C)2014 Elsevier Masson SAS. All rights reserved.