Differentiation of spontaneous and induced mammary adenocarcinomas of the rat by gene expression profiling

被引：4
|
作者：
Marxfeld, Heike
Grenet, Olivier
Bringel, Josiane
Staedtler, Frank
Harleman, Johannes H.
机构：
[1] Novartis Pharma AG, Preclin Safety, Basel, Switzerland
[2] Novartis Pharma AG, Biomarker Dev, Basel, Switzerland
[3] Univ Hannover, Dept Pathol, D-30167 Hannover, Germany
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2006年 / 58卷 / 2-3期
关键词：
gene expression profiling; mammary adenocarcinoma; rat; FGF-3; RMT-1;
D O I：
10.1016/j.etp.2006.06.008
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The differentiation of spontaneous and induced adenocarcinomas is of interest in the setting of carcinogenicity studies. In the experiment reported here, a differentiation of morphologically similar spontaneous and induced mammary adenocarcinomas of the rat is achieved by gene expression profiling. By choosing one marker gene based on the gene expression profile for each tumour type, we were able to distinguish the tumours by real-time quantitative polymerase chain reaction (RT-QPCR) as well. (c) 2006 Elsevier GmbH. All rights reserved.
引用
收藏
页码：151 / 161
页数：11
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