International Union of Pharmacology. LX. Retinoic acid receptors

被引：307
|
作者：
Germain, Pierre
Chambon, Pierre
Eichele, Gregor
Evans, Ronald M.
Lazar, Mitchell A.
Leid, Mark
De Lera, Angel R.
Lotan, Reuben
Mangelsdorf, David J.
Gronemeyer, Hinrich
机构：
[1] Univ Strasbourg 1, INSERM, Inst Genet & Biol Mol & Cellulaire, CNRS, Illkirch Graffenstaden, France
[2] Max Planck Inst Expt Endocrinol, Hannover, Germany
[3] Salk Inst Biol Studies, Howard Hughes Med Inst, Gene Express Lab, La Jolla, CA 92037 USA
[4] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Dept Med, Philadelphia, PA 19104 USA
[5] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
[6] Oregon State Univ, Mol & Cellular Biol Program, Corvallis, OR 97331 USA
[7] Univ Vigo, Fac Quim, Dept Quim Organ, Vigo, Galicia, Spain
[8] Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Unit 432, Houston, TX 77030 USA
[9] Univ Texas, SW Med Ctr, Dept Pharmacol, Howard Hughes Med Inst, Dallas, TX 75235 USA
来源：
PHARMACOLOGICAL REVIEWS | 2006年 / 58卷 / 04期
关键词：
D O I：
10.1124/pr.58.4.4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors. Copyright © 2006 by The American Society for Pharmacology and Experimental Therapeutics.
引用
收藏
页码：712 / 725
页数：14
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